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Published on: September 20, 2016
New disaccharoside from Camptosorus sibiricus Rupr
Ning Li1, Xian Li, Bai-Ling Hou
1Department of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Natural Product Research
|November 22, 2008
Summary
Two disaccharides were isolated from Camptosorus sibiricus, including a novel compound. Their anti-tumor activities were evaluated against human cancer cell lines, marking a first for this genus.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Camptosorus sibiricus Rupr. is a fern species.
- Ethanol extracts of plants are often screened for bioactive compounds.
Purpose of the Study:
- To isolate and characterize compounds from Camptosorus sibiricus.
- To evaluate the anti-tumor potential of isolated compounds.
Main Methods:
- Isolation of compounds using ethanol extraction.
- Structure elucidation via chemical hydrolysis and spectroscopic techniques (IR, 1D and 2D NMR, ESI-MS).
- Anti-tumor activity assessment using the MTT assay against human tumor cell lines.
Main Results:
- A known disaccharose (beta-D-glucopyranosyl (1 --> 2)-beta-D-glucopyranoside) and a new disaccharoside (Octane-1-en-3-ol-3-O-beta-D-glucopyranosyl (1 --> 2)-beta-D-glucopyranoside) were identified.
- These compounds represent the first isolation from the Camptosorus genus.
- Initial anti-tumor activity screening was performed.
Conclusions:
- The chemical structures of two disaccharides from Camptosorus sibiricus were determined.
- The anti-tumor activities of these compounds were preliminarily investigated.
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