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Updated: Jun 27, 2026

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Published on: April 11, 2016
Dynamic relationships between catecholamine-induced shifts of pressure and blood flow in pulmonary artery
B I Tkachenko1, V I Evlakhov, I Z Poyassov
1Department of Visceral Systems Physiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Abstract:
Experiments on cats showed that catecholamines produced maximum changes in pulmonary artery blood pressure during 12-16 sec postinjection, while blood flow in this artery attained maximum only to 40 sec postinjection, i.e. changes in blood flow attained maximum and ended later than blood pressure shifts. Intravenous epinephrine produced bidirectional changes in blood pressure, while norepinephrine always elevated blood pressure in the pulmonary artery; pulmonary circulation increased after injection of both catecholamines.
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