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[Differences among bisfosfonates--specificity of risedronate (Actonel)]

Zlatko Giljević1

  • 1Zavod za endokrinologiju i bolesti metabolizma, Klinika za unutarnje bolesti Klinicki bolnicki centar Zagreb.

Reumatizam
|November 26, 2008
PubMed

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Acetoacetic ester synthesis is a method to obtain ketones from alkyl halides and β-keto esters. The reaction occurs in the presence of an alkoxide base that abstracts the acidic proton of the β-keto esters. The step results in an enolate ion which is doubly stabilized. The enolate then reacts with an alkyl halide via the SN2 process to produce an alkylated ester intermediate with a new C–C bond. The hydrolysis of the intermediate, followed by acidification, results in an alkylated β-keto acid.
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Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
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