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Updated: Jun 27, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
[Initial immunoreaction study on PVA/n-HA + PA66 biological composite material after being implanted into animal
Tao Guo1, Tian-fu Yang, Jia-qi Wu
1Department of Orthopedic, West China Hospital, Sichuan University, Chengdu, China.
Objective:
To observe immunoreaction to PVA/n-HA+ PA66 biological composite material after being implanted into animal body.
Methods:
PVA/n-HA+PA66 composite materials were implanted into mouse subcutaneous tissue. Histologial examination was performed at 2, 4, 6 weeks, the amount of CD3, CD4+, CD8+ in blood and IL-1, IL-6, TNF-alpha in spleen cells was measured at the same time.
Results:
The amount of CD3, CD4+, CD8+ in mouse blood and IL-1, IL-6, TNF-alpha in mouse spleen cells were not different with the control groups at 2, 4, 6 weeks (P > 0.05). The fibrous tissue and some blood vessels were found growing into the porous materials, which resulted in composite materials intergration of proliferative structure. The reject reaction was not found.
Conclusion:
PVA/n-HA+PA66 biological composite material does not cause immune rejection after being implanted into animal body, verifying its good biocompatibility.
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