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Updated: Jun 9, 2026
04:56
Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
Published on: December 30, 2025
Dysregulated KIF2A correlates with p53 expression pattern in breast cancer.
Yun Hao1, Si-Qin Ma2, Ting Xu3
1Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, China.
Molecular and Cellular Biochemistry
|June 8, 2026
Summary
Kinesin family member 2A (KIF2A) and p53 are linked in breast cancer progression. High KIF2A expression and abnormal p53 predict poor outcomes, suggesting a combined prognostic role.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Kinesin family member 2A (KIF2A) and p53 are implicated in tumor development.
- Their specific correlation and prognostic significance in breast cancer are not well-defined.
Purpose of the Study:
- To investigate the expression patterns of KIF2A and p53 in breast cancer.
- To analyze their association with clinicopathological features, patient prognosis, and their interrelationship.
Main Methods:
- Immunohistochemistry (IHC) was performed on 357 breast cancer specimens.
- KIF2A expression and subcellular localization (nuclear-enriched, cytoplasmic-enriched) were assessed.
- p53 expression patterns (wild-type, overexpression, null) were analyzed.
Main Results:
- High KIF2A expression and cytoplasmic localization correlated with aggressive features (HER2-positive, lymph node metastasis, high Ki67, advanced TNM stage) and poor prognosis.
- Abnormal p53 expression (overexpression/null) was linked to metastasis, high grade, ER/PR-negative, HER2-positive status, high Ki67, and triple-negative subtypes, with progressively worse prognosis.
- Combined KIF2A and p53 status improved prognostic stratification, and KIF2A was upregulated in tumors with abnormal p53.
Conclusions:
- KIF2A expression and localization, along with p53 status, are significant prognostic factors in breast cancer.
- The interplay between KIF2A and p53 offers potential insights into breast cancer pathogenesis and therapeutic strategies.
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