Related Experiment Video
Updated: Jun 27, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
Published on: December 24, 2015
Cord blood-derived mesenchymal stem cell does not stimulate nor inhibits T lymphocytes activation
C K Tong1, H F Seow, R Ramasamy
1Department of Pathology, Faculty of Medicine and Health Sciences, University Putra, Malaysia.
Abstract:
The immune modulatory properties of mesenchymal stem cell (MSC) had brought a new insight in cell-based neotherapy. However, recent works of MSC are focused exclusively on bone marrow-derived MSC. We evaluated the immunogenicity of cord blood-derived MSC (CB-MSC) on T lymphocytes. Human peripheral blood mononuclear cells (PBMC) were prepared by density gradient separation and culture with the presence or absence of CB-MSC. PBMC were collected for activation analysis by flow cytometry at 24-, 48-, and 72- hours. The results showed that, CB-MSC does not stimulate nor inhibit T lymphocyte activation.
Related Concept Videos
Mesenchymal Stem Cells
Regulation of Hematopoietic Stem Cells
Multipotency of Hematopoietic Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
