Related Experiment Video
Updated: Jun 27, 2026

11:43
Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors
Published on: May 31, 2012
Average daily quantities: a tool for measuring prescribing volume in England
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
Pharmacoepidemiology and Drug Safety
|November 26, 2008
Summary
A new unit, Average Daily Quantities (ADQs), was developed to measure drug prescribing volume. This system aids discussions with doctors and supports drug utilization research in England.
Area of Science:
- Pharmacology
- Health Services Research
Background:
- Current methods for measuring prescribing volume, such as prescription items and Defined Daily Doses (DDDs), have limitations.
- A need exists for a clear, English-language unit to facilitate discussions about prescribing practices with healthcare professionals.
Purpose of the Study:
- To develop a new, understandable unit for measuring drug prescribing volume in England.
- To create a tool that aids in discussions regarding prescribing with doctors and supports drug utilization research.
Main Methods:
- An expert group was convened to establish Average Daily Quantities (ADQs) for key drug categories.
- ADQ values were determined using Defined Daily Doses (DDDs), average prescribed daily doses, and therapeutic equivalence data.
Main Results:
- The developed Average Daily Quantities (ADQs) provide a practical unit for assessing prescribing volume.
- This system is valuable for both clinical discussions and drug utilization studies.
Conclusions:
- Average Daily Quantities (ADQs) offer a more accessible and useful measure for prescribing volume compared to existing units.
- Regular review of ADQ values will ensure their continued relevance and accuracy in reflecting prescribing patterns and drug information.
Related Concept Videos
Glassware Calibration
Accurate calibration of glassware, such as volumetric flasks, pipettes, and burettes, is essential to ensure accurate measurements in the analytical laboratory. Calibration helps maintain consistency across measurements and prevents errors arising from inaccurate volumes.
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
Drug Concentrations: Measurements
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma —...
Plasma —...
Dosage Regimen Designs: Nomograms and Tabulations
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
Drug Dosing: Infants and Children
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Drug Dosage Regimen: Overview
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Drug Distribution: Volume of Distribution
The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.