Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

Fungal Phylum Basidiomycota

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...

Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

Fungal Phylum Ascomycota

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...

Tuberculosis

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

Biosynthesis of Lipids

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Denosumab is Associated with Improved Liver Function and Reduced Fibrosis Scores in Patients with Metabolic Dysfunction-associated Steatotic Liver Disease and Osteoporosis: A Retrospective Observational Study.

Endocrine, metabolic & immune disorders drug targets·2026

Same author

Ginsenoside Rg1 alleviates post-ischemic stroke neuroinflammation by inhibiting CKLF1-mediated suppression of dead/dying neuron clearance.

Acta pharmaceutica Sinica. B·2026

Same author

The dyadic paradox of unmet supportive care needs and depression in colorectal cancer couples: an explanatory sequential mixed-methods study.

Frontiers in psychology·2026

Same author

When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models.

Adipocyte·2026

Same author

BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage-myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis.

Theranostics·2026

Same author

miR-192-5p targets USP1 to regulate osteogenic differentiation and diagnose the occurrence of osteoporotic fracture.

BMC musculoskeletal disorders·2026

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Diterpenoids of macromycetes.

Jin-Wen Shen¹, Yuan Ruan, Bing-Ji Ma

¹College of Life Sciences, Henan Agricultural University, Zhengzhou, P.R. China.

Journal of Basic Microbiology

|November 26, 2008

Summary

This review covers diterpenoids from mushroom fruiting bodies and mycelial cultures, focusing on isolation, structure, and bioactivity up to 2007. It also explores fermentation conditions for macromycetes.

Area of Science:

Natural Product Chemistry
Mycology
Pharmacognosy

Background:

Diterpenoids are a diverse class of natural products with significant biological activities.
Macromycetes, or higher fungi, are prolific sources of unique chemical compounds.
Research into fungal metabolites is crucial for discovering new therapeutic agents.

Purpose of the Study:

To comprehensively review the isolation, structure elucidation, and bioactivity of diterpenoids from macromycete fruiting bodies.
To examine diterpenoids produced by macromycetes in mycelial culture.
To investigate culture conditions influencing diterpenoid fermentation in macromycetes.

Main Methods:

Literature survey of chemical and biological studies on fungal diterpenoids up to December 2007.

More Related Videos

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Analysis of research on diterpenoids from both fruiting bodies and mycelial cultures.

Review of studies on fermentation parameters for macromycete cultivation.

Main Results:

Compilation of known diterpenoids from various macromycete species.
Identification of structure-activity relationships for selected diterpenoids.
Overview of successful cultivation and fermentation strategies for producing diterpenoids.

Conclusions:

Macromycetes are a valuable resource for diterpenoid discovery.
Mycelial cultures offer a sustainable alternative for producing fungal diterpenoids.
Further research into fermentation optimization can enhance diterpenoid yields and diversity.