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Updated: Jun 27, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Complete multinuclear magnetic resonance characterization of a set of polyfluorinated acids and alcohols
Alexander A Marchione1, Robert C Buck
1DuPont Central Research and Development, Experimental Station, Wilmington, DE 19880, USA. alexander.a.marchione@usa.dupont.com
Abstract:
A complete (1)H, (19)F, and (13)C NMR assignment of a homologous series of polyfluorinated acids and alcohols is reported. These assignments were obtained chiefly through single and multiple-bond (1)H-(13)C and (19)F-(13)C correlation experiments (HSQC, HMBC). (19)F NOESY experiments were required for assignment of two compounds with diastereotopic (19)F nuclei in the CF(2)chain of the molecule.
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