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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jun 27, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Innate immunity in asthma.

Jodie L Simpson1, Collin Brooks, Jeroen Douwes

  • 1NHMRC Centre for Respiratory and Sleep Medicine, The University of Newcastle, Newcastle, Australia. Jodie.simpson@hnehealth.nsw.gov.au

Paediatric Respiratory Reviews
|November 26, 2008
PubMed
Summary

Asthma is complex, involving non-allergic causes in half of cases. The innate immune system plays a key role in asthma development and protection, influenced by exposure timing and type.

Area of Science:

  • Immunology
  • Pulmonology
  • Allergy and Clinical Immunology

Background:

  • Asthma is a complex respiratory condition with diverse etiologies.
  • Non-eosinophilic asthma, often non-allergic, constitutes up to 50% of cases.
  • The innate immune system's role in asthma is increasingly recognized.

Purpose of the Study:

  • To explore the involvement of the innate immune system in asthma.
  • To understand factors influencing the innate immune response in asthma.
  • To identify potential new therapeutic targets for asthma management.

Main Methods:

  • Review of current evidence on innate immunity in asthma.
  • Analysis of non-allergic asthma triggers and their mechanisms.
  • Discussion of gene-environment interactions in asthma pathogenesis.

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 27, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Main Results:

  • The innate immune system responds to non-allergic triggers like viral and bacterial components.
  • Innate immune responses can contribute to both asthma development and protection.
  • Exposure timing, asthma inflammatory subtype, and dose influence the immune response.

Conclusions:

  • Asthma's complexity extends beyond allergy and eosinophilia, involving innate immunity.
  • Understanding innate immune mechanisms is crucial for novel asthma therapies.
  • Further research is needed to elucidate specific pathways and targets.