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Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
Published on: November 22, 2024
Plasmodium falciparum: organelle-specific acquisition of lipoic acid
Svenja Günther1, Janet Storm, Sylke Müller
1Division of Infection & Immunity, Glasgow Biomedical Research Centre, Faculty of Biomedical Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.
Abstract:
Lipoic acid is an essential cofactor of multienzyme complexes that are integral to energy metabolism, amino acid degradation and folate metabolism. In recent years it has been shown that the malaria parasite Plasmodium falciparum possesses organelle-specific pathways that guarantee the lipoylation of their multienzyme complexes which occur in the mitochondrion (LA salvage) and in a plastid-like organelle, the apicoplast (LA biosynthesis). The unique distribution of the lipoylation machineries and the unique metabolic requirements of the parasites present a situation that is potentially exploitable for new ways to improve malaria control.
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