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Updated: Jun 27, 2026

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Published on: June 27, 2025
Outcomes of pregnancies affected by hemoglobin H disease
Theera Tongsong1, Kasemsri Srisupundit, Suchaya Luewan
1Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. ttongson@mail.med.cmu.ac.th
Objective:
To determine the outcomes of pregnancies affected by hemoglobin H (HbH) disease.
Methods:
A retrospective cohort study was conducted with 120 women with singleton pregnancies complicated by HbH disease only. The controls-to-cases ratio was 2:1.
Results:
Maternal outcomes were similar in the 2 groups. The incidences of fetal growth restriction (relative risk [RR], 2.4; 95% confidence interval [CI], 1.60-3.50), preterm birth (RR, 1.4; 95% CI, 1.03-1.96), and low birth weight (RR, 1.9; 95% CI, 1.46-2.56) were significantly higher in the study than in the control group. The perinatal mortality rate was slightly higher in the study group.
Conclusion:
In spite of attempts to keep hemoglobin levels sufficiently high (>7.0 g/dL), pregnancies with HbH disease were significantly associated with increased risks of fetal growth restriction, preterm birth, and low birth weight.
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