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Updated: Jun 27, 2026
12:22
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
[Herpes zoster in old adults]
Pierre-Olivier Lang1, Joël Belmin, Jean-Pierre Michel
1Département de réhabilitation et gériatrie, Faculté de médecine et Hôpitaux universitaires de Genève, CH-1226 Thônex-Genève, Suisse. Pierre.O.Lang@hcuge.ch
Presse Medicale (Paris, France : 1983)
|November 26, 2008
Summary
Varicella-zoster virus causes chickenpox and shingles. A new vaccine (Zostavax) now prevents shingles and its painful complication, postherpetic neuralgia, in older adults.
Area of Science:
- Virology
- Immunology
- Epidemiology
Context:
- Varicella-zoster virus (VZV) causes chickenpox and later reactivation as herpes zoster (shingles).
- Shingles often affects elderly patients, causing severe pain and complications like postherpetic neuralgia (PHN).
- PHN is a debilitating pain syndrome persisting over 30 days post-rash.
Purpose:
- To review the pathophysiology of VZV reactivation and its complications.
- To discuss current therapeutic options for managing herpes zoster and PHN.
- To highlight advancements in primary prevention strategies for VZV reactivation.
Summary:
- Systemic antiviral medications can alleviate shingles severity, reduce acute pain, and lower PHN incidence.
- A significant breakthrough in primary prevention is the development and approval of a vaccine (Zostavax).
- This vaccine is indicated for individuals aged 60 and older to prevent herpes zoster and PHN.
Impact:
- Antiviral therapies offer symptomatic relief and reduce complication rates.
- Vaccination represents a crucial step in preventing herpes zoster and its sequelae.
- Improved prevention and treatment strategies enhance the quality of life for aging populations susceptible to VZV reactivation.
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