Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thrombolytic treatment of right atrial thrombus in a patient with B cell acute lymphoblastic leukemia: a case report.

Indian journal of thoracic and cardiovascular surgery·2023

Same author

Effect of Preoperative Skin Preparation Methods on Sternotomy Surgical Site Infection Rates: A Quasi-Experimental Study.

Wound management & prevention·2022

Same author

Which proteinase-activated receptor-1 antagonist is better?: Evaluation of vorapaxar and parmodulin-2 effects on human left internal mammary artery endothelial function.

Life sciences·2021

Same author

A bridge to transplantation: The life experiences of patients with a left ventricular assist device.

Heart & lung : the journal of critical care·2020

Same author

Early postoperative rupture of Heartware outflow graft: A case report.

Journal of cardiac surgery·2019

Same author

Saphenous vein diameter is a single risk factor for early recanalization after endothermal ablation of incompetent great saphenous vein.

Vascular·2019

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

Heart transplantation.

Ozan Erbasan¹, Cemal Kemaloğlu, Omer Bayezid

¹Department of Cardiovascular Surgery, Faculty of Medicine, Akdeniz University, Antalya, Turkey. ozzan70@gmail.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology

|December 11, 2008

Summary

This summary is machine-generated.

Heart transplantation offers improved survival and quality of life for end-stage heart failure patients. Despite advancements, donor organ scarcity remains a significant challenge for this life-saving procedure.

More Related Videos

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Related Experiment Videos

Last Updated: Jun 27, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Area of Science:

Cardiology
Transplantation Medicine
Surgical Innovation

Background:

End-stage heart failure significantly reduces patient quality of life and prognosis, with less than 50% one-year survival.
Heart transplantation is the definitive treatment for irreversible end-stage heart failure across all age groups.
Despite its efficacy, donor organ availability limits the widespread application of heart transplantation.

Purpose of the Study:

To evaluate the outcomes and impact of heart transplantation on patients with end-stage heart failure.
To highlight the survival rates and quality of life improvements post-transplantation.
To underscore the persistent challenge of donor organ shortage in heart transplantation.

Main Methods:

Review of survival data and functional status assessments in heart transplant recipients.
Analysis of long-term survival statistics following heart transplantation.
Comparison of pre-operative and post-operative New York Heart Association (NYHA) functional classes.

Main Results:

Heart transplant recipients show significantly improved survival rates: 86% at one year and over 50% at 10 years.
Approximately 50% of patients survive beyond 10 years, with 25% living over 18 years post-transplantation.
Patients' functional status improves dramatically, with most transitioning from NYHA class III-IV to I-II post-transplant.

Conclusions:

Heart transplantation substantially enhances both survival and quality of life for end-stage heart failure patients.
Long-term survival rates following heart transplantation have seen considerable improvement.
The critical shortage of donor hearts remains the primary obstacle to increasing the number of heart transplantations performed.