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Related Experiment Video

Updated: Jun 27, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

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Serial functional imaging poststroke reveals visual cortex reorganization.

Amy Brodtmann1, Aina Puce, David Darby

  • 1National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg, Melbourne, Australia. amyb@alphalink.com.au

Neurorehabilitation and Neural Repair
|November 26, 2008
PubMed
Summary
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Stroke impacts visual cortex function, causing reduced activation in striate and ventral areas. However, the dorsal visual system may compensate, offering potential for new visual rehabilitation strategies.

Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Visual cortical reorganization after brain injury is not well understood.
  • Functional magnetic resonance imaging (fMRI) can assess brain activity.

Purpose of the Study:

  • To investigate early and late cortical activation patterns in patients with visual cortex infarction using fMRI.
  • To evaluate visual cortical reorganization following stroke.

Main Methods:

  • Serial fMRI scans were performed on stroke patients within 10 days and at 6 months post-stroke.
  • A high-level visual task targeted ventral extrastriate cortex activation.
  • Patient data were compared to age-matched healthy controls.

Main Results:

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Last Updated: Jun 27, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

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Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
06:45

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

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  • Stroke patients showed reduced bilateral striate and ventral extrastriate activation compared to controls.
  • Dorsal extrastriate cortex activation remained comparable to controls.
  • Increased signal change was observed in dorsal visual sites in patients.

Conclusions:

  • Stroke leads to bilateral functional depression of striate and ventral visual cortices.
  • The dorsal visual system may be utilized or act as a surrogate following stroke.
  • This dorsal activity presents a potential target for visual rehabilitation therapies.