Using long-acting stimulants: does it change ADHD treatment outcome?
James M Swanson1, Lily Hechtman
1Professor of Pediatrics, UCI Child Development Center, Centerpointe Plaza, 19722 MacArthur Blvd., University of California at Irvine, Irvine, California 92612, (949) 824-1822 (Phone), (949) 824-1811 (Fax), jmswanso@uci.edu (Email).
Summary
New long-acting medications for Attention Deficit Hyperactivity Disorder (ADHD) show improved remission rates. Extended-release formulations offer sustained symptom control, enhancing treatment efficacy for children with ADHD.
Area of Science:
- Pediatric Psychiatry
- Pharmacology
Background:
- Many children with Attention Deficit Hyperactivity Disorder (ADHD) do not achieve full remission with current multimodal interventions.
- Development of novel long-acting medications aims to improve treatment outcomes for ADHD.
Purpose of the Study:
- To summarize the development and efficacy of new long-acting stimulant medications for ADHD.
- To compare the effectiveness of extended-release methylphenidate (MPH) with immediate-release MPH.
Main Methods:
- Review of presentations on long-acting ADHD drug development from the 2004 Canadian Academy of Child and Adolescent Psychiatry Annual Meeting.
- Analysis of clinical studies on the efficacy of extended-release formulations, including OROS-MPH and Adderall XR.
Main Results:
- Concerta(R) OROS-MPH delivers methylphenidate (MPH) over 12 hours, maintaining symptom control and academic productivity.
- OROS-MPH demonstrated significantly higher remission rates (44%) compared to immediate-release MPH (16%) in an 8-week trial.
- Efficacy of OROS-MPH was sustained over a 12-month study period.
Conclusions:
- Long-acting stimulant formulations represent a significant advancement in ADHD treatment.
- These novel drug delivery systems have transformed clinical practice for Attention Deficit Hyperactivity Disorder.
Keywords:
Adderall XR®Amphetamine saltsAttention Deficit/Hyperactivity DisorderMethylphenidateOROS-MPHMore Related Videos
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