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8-Nitroguanosines as chemical probes of the protein S-guanylation

Yohei Saito1, Hirobumi Taguchi, Shigemoto Fujii

  • 1Graduate School of Life Sciences, Tohoku University, Aoba-ku, 981-8555, Sendai, Japan.

Chemical Communications (Cambridge, England)
|November 26, 2008
PubMed

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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