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Updated: Jun 27, 2026
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NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
Improved synthesis of polyfluorinated L-lysine for 19F NMR-based screening
Beatrice Malgesini1, Eduard Felder, Nicola Mongelli
1Department of Chemistry, BU-Oncology, Nerviano Medical Sciences, Viale Pasteur 10, Nerviano, MI, 20014, Italy. beatrice.malgesini@nervianoms.com
Molecular Diversity
|November 26, 2008
Abstract:
Polyfluorinated N-alpha-Fmoc-is an element of-Boc-L-lysine represents the best-in-class among a set of polyfluorinated amino acids (PFAs) which are useful tools for (19)F NMR-Based Screening. In this communication, optimized reaction conditions that allowed for the multi-gram preparation of this unnatural amino acid are reported.
