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Updated: Jun 27, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
Published on: July 23, 2012
Dendritic cells in rhinitis
Alex Kleinjan1, Bart N Lambrecht
1Department of Pulmonary Medicine, Erasmus M.C, Dr. Molerwaterplein, Rotterdam, The Netherlands. a.kleinjan@erasmusmc.nl
Abstract:
Dendritic cells (DCs) play an important role in all kind of rhinitis and sinusitis. One of the most important upper airway diseases is allergic rhinitis. DCs are the professional antigen presenting cells that have the capacity to present antigen to naive-T cells and T-effector cells. In the context of a broad spectrum of rhinitis, from allergic rhinitis via upper respiratory tract virus infection to chronic sinusitis, DCs have an important role in the immunological outcome of the disease. Studies in humans and animal models that have highlighted the role of DC were evaluated. This article reviews recent information on the involvement of DC in rhinitis, and the mechanisms by which DC could be employed as targets for therapeutic intervention.
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