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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
New cycloartane glycosides from Camptosorus sibiricus Rupr
Peng Zhang1, Yi-Yu Cheng, Zhong-Jun Ma
1Institute of Pharmaceutical Informatics, Zhejiang University in Zijingang Campus, Hangzhou, China.
Abstract:
Three new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr. By means of chemical and spectroscopic methods (IR, 1D, and 2D NMR, HR-MS, ESI-MS), the structures were established as (24R)-3beta,7beta,24,25, 30-pentahydroxycycloartane-3-O-beta-D-glucopyranosyl-(1-->4)-[alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranosyl]-24-O-beta-D-glucopyranoside (1), (24R)-3beta,7beta,24,25,30-pentahydroxycycloartane-3-O-beta-D-glucopyranosyl-(1-->4)-[beta-D-galactopyranosyl-(1-->2)-beta-D-glucopyranosyl]-24-O-beta-D-glucopyranoside (2), (24R)-3beta,7beta,24,25,30-pentahydroxycycloartane-30-O-coumaroyl-3-O-beta-D-glucopyranosyl-24-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (3). At the same time, the new compounds were tested for their cytotoxicities in vitro against human tumor cell lines (A375-S2, Hela) using MTT method.
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