Related Experiment Video
Updated: Jun 27, 2026
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Accuracy and definitive interpretation of preoperative technetium 99m sestamibi imaging based on the discipline of
Ayesha N Khalid1, Christopher S Hollenbeak, Bruce W Higginbotham
1Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Sciences University, Portland, OR, USA.
Background:
Technetium 99m sestamibi scans have become a principal means of localizing parathyroid adenomas. Its accuracy and reliability has allowed for the proliferation of minimal access parathyroidectomy. Localizing interpretation of these scans often drives referral of hyperparathyroid patients for surgery. Interpretation of these scans may differ between nuclear medicine physicians and surgeons.
Methods:
We reviewed patients (N = 65) with digital images from an academic medical center with the diagnosis of primary hyperparathyroidism. We assessed the willingness to define an adenoma's location, the interrater reliability, and the accuracy of technetium (Tc-99m) sestamibi read by a surgeon and a nuclear medicine physician.
Results:
There was poor correlation between both readers for assessment of quality of images (k = 0.54, 0.07) but very good correlation for adenoma location (k = 0.81).
Conclusion:
Both readers had good accuracy in predicting the location of the parathyroid adenoma. The surgeon was more likely to call a scan positive.
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