Related Experiment Video

Updated: Jun 27, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Left ventricular systolic dyssynchrony is a predictor of cardiac remodeling after myocardial infarction

Yan Zhang1, Gabriel W Yip, Anna K Y Chan

  • 1Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, PR China.

American Heart Journal
|November 27, 2008
PubMed

Insights

Early assessment of left ventricular (LV) dyssynchrony using tissue Doppler imaging can predict progressive LV remodeling after acute myocardial infarction (MI). This novel predictor is independent and incremental to infarct size, aiding in risk stratification.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Research

Background:

  • Acute myocardial infarction (MI) can lead to adverse left ventricular (LV) remodeling and dysfunction.
  • Predictive markers for post-MI LV remodeling are crucial for timely intervention.
  • Conventional assessments may not fully capture the risk of progressive cardiac changes.

Purpose of the Study:

  • To evaluate if early assessment of LV dyssynchrony by tissue Doppler imaging predicts progressive ventricular enlargement and dysfunction post-MI.
  • To determine the independent and incremental predictive value of LV dyssynchrony compared to infarct size.

Main Methods:

  • Prospective study of 47 patients with normal QRS duration post-MI.
  • Tissue Doppler imaging and contrast-enhanced cardiac magnetic resonance imaging (Ce-MRI) performed at multiple time points.
  • Calculation of systolic dyssynchrony index (Ts-SD) and infarct size (IS).

Main Results:

  • Patients with LV remodeling showed significantly higher initial IS and Ts-SD.
  • Ts-SD and IS were independent predictors of progressive LV remodeling.
  • A Ts-SD cutoff of >= 45 milliseconds accurately predicted LV remodeling at 1 year (90.5% sensitivity, 90.9% specificity).

Conclusions:

  • Left ventricular systolic dyssynchrony is a novel, independent predictor of chronic LV remodeling after MI.
  • Early Ts-SD assessment provides incremental prognostic information beyond IS and conventional methods.
  • This finding may improve risk stratification and management strategies for post-MI patients.
Abstract

More Related Videos

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...