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Related Experiment Videos

[Therapy-refractory fulminant meningococcal sepsis].

A Eigentler1, P Lechleitner, C Wiedermann

  • 1Bundesstaatliche bakteriologisch-serologische Untersuchungsanstalt, Universität Innsbruck.

Deutsche Medizinische Wochenschrift (1946)
|May 17, 1991
PubMed
Summary

Severe meningococcal infection can rapidly cause life-threatening consumptive coagulopathy and shock. Early recognition of Neisseria meningitidis is crucial, even without meningitis symptoms.

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Area of Science:

  • Infectious Diseases
  • Hematology

Background:

  • Meningococcal infection, caused by Neisseria meningitidis, is a serious bacterial illness.
  • Severe forms can lead to rapid deterioration and complications such as coagulopathy.

Observation:

  • Two pediatric cases presented with sudden fever, petechiae, and rapid progression.
  • Neither patient exhibited clinical signs of meningitis, complicating early diagnosis.

Findings:

  • Both patients developed severe consumptive coagulopathy, characterized by abnormal prothrombin, PTT, fibrinogen, and platelet counts.
  • One patient experienced treatment-resistant shock, while the other developed profound anemia, leading to fatal outcomes in both.
  • Neisseria meningitidis was isolated from blood cultures, confirming meningococcal sepsis.

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Implications:

  • Highlights the critical need for prompt diagnosis and management of meningococcal sepsis, particularly in cases presenting without typical meningitis signs.
  • Underscores the potential for rapid progression to consumptive coagulopathy and shock, necessitating aggressive supportive care.
  • Emphasizes the importance of blood cultures for identifying Neisseria meningitidis in severe febrile illnesses with petechial rash.