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Updated: Jun 27, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Knowledge translation in everyday nursing: from evidence-based to inquiry-based practice.

Gweneth Hartrick Doane¹, Colleen Varcoe

¹School of Nursing, University of Victoria, Victoria, Canada. gdoane@uvic.ca

ANS. Advances in Nursing Science

|November 27, 2008

Summary

Understanding nursing practice requires examining ontology and epistemology, not just epistemology. Effective knowledge translation involves embodied ontological inquiry, integrating theory and evidence into nursing actions for better patient care.

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Last Updated: Jun 27, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Area of Science:

Nursing
Philosophy of Science
Knowledge Translation

Background:

The link between theory, evidence, and practice in nursing is often viewed through an epistemological lens.
This perspective overlooks the crucial role of ontology in nursing actions.

Purpose of the Study:

To shift the focus from epistemology to ontology in understanding the theory-evidence-practice connection.
To explore how ontological inquiry at the action level is essential for effective knowledge translation in nursing.

Main Methods:

Utilizing deconstructive hermeneutics.
Analyzing a nursing practice example to illustrate knowledge translation complexities.
Examining the embodied nature of integrating knowledge into practice.

Main Results:

Effective knowledge integration in nursing is an embodied ontological process.
Ontological inquiry at the action level is necessary to understand and influence the theory-evidence-practice interconnection.
This process involves drawing on theory and evidence to expand possibilities for action within specific contexts.

Conclusions:

Nursing actions are shaped by the intertwined nature of epistemology and ontology.
Embodied ontological inquiry is key to effectively translating knowledge into nursing practice.
A shift towards ontological considerations enhances the integration of theory and evidence into nursing care.