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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 27, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Liver involvement in celiac disease.

A Rubio-Tapia1, J A Murray

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Minerva Medica
|November 27, 2008
PubMed
Summary

Celiac disease, an immune disorder, frequently causes liver issues like elevated enzymes, often resolving with a gluten-free diet. It can also present alongside severe liver conditions, with mechanisms still under investigation.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Immunology

Background:

  • Celiac disease is a chronic immune-mediated disorder affecting multiple organs.
  • Liver abnormalities, including elevated liver enzymes and mild histologic changes ('celiac hepatitis'), are common extraintestinal manifestations.
  • These liver issues often improve with a gluten-free diet, but celiac disease can also link to severe liver disease or coexist with other chronic liver disorders.

Purpose of the Study:

  • To review the spectrum of liver injury associated with celiac disease.
  • To explore the clinical implications of celiac disease in patients with existing chronic liver disorders.
  • To understand the potential pathogenic mechanisms of liver damage in celiac disease.

Main Methods:

  • Literature review of celiac disease and liver injury.

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  • Analysis of clinical presentations and outcomes.
  • Discussion of potential autoimmune and systemic factors involved in pathogenesis.

    • Main Results:

    • Isolated hypertransaminasemia ('celiac hepatitis') is the most frequent liver manifestation.
    • Gluten-free diet typically normalizes liver enzymes and histology.
    • Celiac disease can be associated with severe liver disease and overlap with autoimmune liver conditions.

    Conclusions:

    • Celiac disease presents a spectrum of liver manifestations, from mild enzyme elevations to severe disease.
    • Understanding the link between celiac disease and liver disorders is crucial for patient management.
    • Further research into the pathogenic mechanisms, including genetic and systemic factors, is warranted.