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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Obesity, inflammation, and kidney disease
Maruja Navarro-Díaz1, Assumpta Serra, Dolores López
1Department of Nephrology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Barcelona, Spain.
Kidney International. Supplement
|November 27, 2008
Summary
Obesity is linked to kidney problems through metabolic changes and inflammatory adipocytokines. This review explores the connection between obesity, metabolic syndrome, and kidney disease, including new patient data.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Disorders
Background:
- Obesity is a known risk factor for numerous comorbidities, including cardiovascular disease, dyslipidemia, hypertension, and diabetes mellitus.
- Emerging evidence links obesity and extreme obesity to renal involvement, though the exact mechanisms remain unclear.
- Metabolic alterations and inflammatory adipocytokines are suspected contributors to obesity-related kidney damage.
Purpose of the Study:
- To review the association between inflammatory adipocytokines and metabolic syndrome with renal involvement.
- To explore the physiopathological mechanisms underlying kidney damage in obesity.
- To present findings from a cohort of extremely obese patients.
Main Methods:
- Literature review of epidemiological and pathological studies.
- Analysis of proposed mechanisms involving metabolic alterations and adipocytokines.
- Clinical data review from a cohort of extremely obese individuals.
Main Results:
- Obesity is increasingly recognized as a significant factor in renal disease development.
- Inflammatory adipocytokines and metabolic syndrome are implicated in the pathogenesis of obesity-associated nephropathy.
- Specific findings from the extremely obese patient cohort will be discussed.
Conclusions:
- The link between obesity and kidney disease is supported by growing evidence.
- Understanding the roles of metabolic alterations and adipocytokines is crucial for addressing obesity-related renal complications.
- Further research is needed to fully elucidate and manage these kidney issues.
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