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Updated: Jun 2, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Survivin expression in renal cell carcinoma.
Rosanna Zamparese1, Giuseppe Pannone, Angela Santoro
1Department of Surgical Sciences, University of Foggia, Foggia, Italy.
Cancer Investigation
|November 27, 2008
Summary
Survivin, an apoptosis inhibitor, is linked to aggressive clear cell renal cell carcinoma (ccRCC). Low survivin expression in ccRCC patients correlates with better survival rates, suggesting its prognostic value.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Inhibitors of apoptosis, such as survivin, can promote cancer progression and treatment resistance.
- Deregulated survivin expression is implicated in various cancers, affecting cell viability.
Purpose of the Study:
- To investigate the expression and prognostic significance of survivin in clear cell renal cell carcinoma (ccRCC).
Main Methods:
- Immunohistochemical technique was used to analyze survivin expression.
- The study included a series of 49 clear cell renal cell carcinoma (ccRCC) samples.
Main Results:
- Survivin expression was significantly associated with poorly differentiated, advanced stages, and aggressive ccRCC (p < 0.05).
- Patients with low survivin expression demonstrated statistically significant better survival rates compared to those with high expression (p < 0.05).
Conclusions:
- Survivin expression serves as a potential prognostic marker in ccRCC.
- Findings may inform the design of follow-up protocols and alternative therapeutic strategies for ccRCC.
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