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Updated: Jun 27, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Mouse models for the study of colon carcinogenesis
Daniel W Rosenberg1, Charles Giardina, Takuji Tanaka
1Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030-3101, USA. Rosenberg@uchc.edu
Carcinogenesis
|November 28, 2008
Summary
Mouse models offer valuable insights into colon cancer development, mimicking human disease progression. This review explores carcinogen-induced tumor initiation, genetic influences, and molecular changes relevant to human colorectal cancer.
Area of Science:
- Oncology
- Genetics
- Experimental Pathology
Background:
- Rodent models have been utilized for colon cancer research for nearly 80 years.
- Mouse models provide rapid, reproducible tumor induction and recapitulate the human adenoma-carcinoma sequence.
- Advanced genetic models (transgenic, knock-out, knock-in) enhance the utility of these studies.
Purpose of the Study:
- To review mechanisms of tumor initiation by chemical carcinogens in mouse models.
- To discuss the impact of genetic background on colon carcinogenesis.
- To describe lesion features and molecular alterations in relation to human colorectal cancer pathogenesis.
Main Methods:
- Review of existing literature on experimental colon carcinogenesis in rodents.
- Analysis of mechanisms of tumor initiation by common chemical carcinogens.
- Examination of genetic influences on carcinogen-induced disease progression.
Main Results:
- Chemical carcinogens initiate tumors through specific mechanisms.
- Host genetic background significantly influences the extent and progression of colon cancer.
- Lesions exhibit molecular aberrations that parallel human colorectal cancer development.
Conclusions:
- Carcinogen-induced mouse models are powerful tools for studying colon cancer.
- Understanding genetic influences is crucial for interpreting experimental findings.
- Molecular insights from these models contribute to understanding human colorectal cancer pathogenesis.
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