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Updated: Aug 10, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
Published on: October 23, 2021
Detection, occurrence, development, diagnosis and treatment of vaginal microbiome in gynecological cancers
Han Xia1, Jing Xie2, Xin-Yun Wang3
1International Peace Maternity and Child Health Hospital, School of Medicine. Shanghai Jiao Tong University, Shanghai 200030, China; College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China.
Abstract:
Gynecological cancers, including cervical, endometrial, and ovarian cancers, represent a growing global health burden with increasing incidence and mortality. The vaginal microbiome has emerged as a promising target for early cancer diagnosis and therapeutic intervention. Therefore, this review summarizes the composition and dynamics of the vaginal microbiome, emphasizing its association with the pathogenesis of gynecological cancers through chronic inflammation, immune modulation, and hormonal interactions. Advances in technologies such as 16S rRNA sequencing, metagenomics, and multi-omics have enabled the identification of potential microbial biomarkers. Probiotics, antibiotics, and vaginal microbiota transplantation are treatment technologies of gynecological cancers demonstrating considerable potential in restoring microbial balance and improving clinical outcomes. Furthermore, significant challenges persist in standardizing microbial biomarkers and translating research findings into precision therapies. Future studies should prioritize large-scale clinical validation and develop integrative strategies to harness the potential of the vaginal microbiome for cancer prevention and personalized treatment.
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