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Updated: Jun 27, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
[Pseudo-tumoral and ischemic encephalic Erdheim-Chester disease]
T Amezyane1, A Abouzahir, D Bassou
1Service de médecine interne B, hôpital militaire d'instruction Mohammed-V, 10000 Hay Ryad, Rabat, Maroc. amez.tao@caramail.com
Introduction:
Erdheim-Chester disease (ECD) is a rare non-langerhans cell histiocytosis of unknown etiology. It is a multi-systematic xanthogranulomatous infiltration with almost constant bone involvement; the neurological manifestations are not specific and occur in 15-20% of cases.
Methods:
We report the case of a 59-year-old woman hospitalized for a frontal syndrome and right hemiparesis.
Results:
Imaging revealed a left caudate nucleus process with recent infarct. Cardiovascular involvement and bilateral osteosclerosis of long bones strongly suggested ECD, confirmed after biopsies of the pericardium and bone.
Conclusion:
Pseudo-tumor encephalic ECD is very rare; the caudate nuclei is an unusual localization; ischemic stroke has been exceptionally described. Prognosis depends largely on the involvement of the central nervous and cardiovascular systems.
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