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Enhanced contractile effect of phorbol dibutyrate in portal veins from hypertensive rats
N Miyata1, K Tsuchida, S Otomo
1Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Biochemical and Biophysical Research Communications
|May 15, 1991
Abstract:
The effects of phorbol 12,13-dibutyrate (PDBu) on portal veins from hypertensive (SHRSP0 and normotensive (WKY) rats were examined. PDBu contracted the strips from SHRSP and WKY in a concentration-dependent manner. However, both twitch contraction and tonic contraction of strips in response to PDBu were enhanced in SHRSP. Treatment with staurosporine reduced contractile response to PDBu in strips from SHRSP. It appears that the activity of protein kinase C in vascular smooth muscle is increased in SHRSP.