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Treatment strategies for Behçet's disease

Izzet Fresko1, Hasan Yazici

  • 1Department of Rheumatology, Cerrahpasa Medical Faculty, Cerrahpasa Tip Fakultesi, Ic Hastaliklari ABD, 34300 Aksaray, Istanbul, Turkey. izzetfresko@yahoo.com

Expert Opinion on Pharmacotherapy
|December 2, 2008
PubMed

Insights

Behçet

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Behçet's disease (BD) is a multisystemic vasculitis with diverse clinical manifestations, including oral/genital ulcers, skin lesions, uveitis, and systemic involvement of blood vessels, CNS, and GI tract.
  • BD prevalence varies geographically, being rare in Western countries but common in the Middle and Far East.

Purpose of the Study:

  • To review and discuss current treatment strategies for Behçet's disease.
  • To explore the range of therapeutic options, from conservative management to intensive immunosuppressive therapy.

Main Methods:

  • A systematic literature search was conducted using Cochrane and Medline databases in June 2008.
  • European League Against Rheumatism (EULAR) recommendations for BD management were incorporated.

Main Results:

  • Significant advancements in managing ocular and musculoskeletal manifestations of BD have been observed over the past two decades.

Conclusions:

  • While progress has been made in certain aspects of Behçet's disease management, challenges persist in treating thrombophlebitis, CNS, and gastrointestinal involvement.
Abstract

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