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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: Jun 27, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic marks in melanoma.

Hunter W Richards¹, Estela E Medrano

¹Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.

Pigment Cell & Melanoma Research

|December 2, 2008

Summary

This summary is machine-generated.

This study reviews epigenetic research in melanoma, focusing on how DNA and chromatin structural changes influence cancer growth. It explores modifying the epigenetic landscape to inhibit melanoma and identify new diagnostic markers.

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Last Updated: Jun 27, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Published on: April 5, 2018

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Published on: June 7, 2019

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Oncology
Epigenetics
Dermatology

Background:

Melanoma is a heterogeneous skin cancer with diverse subtypes and colors.
Nuclear architecture changes in melanoma reflect genomic and non-genomic alterations.
Epigenetic modifications, including DNA methylation and histone alterations, are increasingly recognized in cancer.

Purpose of the Study:

To review current epigenetic research in melanoma skin cancers.
To discuss strategies for modifying the melanoma epigenetic landscape to inhibit tumor growth.
To propose novel approaches for identifying melanoma biomarkers.

Main Methods:

Review of existing literature on melanoma epigenetics.
Analysis of genomic and chromatin structural changes in melanoma.
Exploration of therapeutic strategies targeting epigenetic modifications.

Main Results:

Epigenetic alterations, particularly histone modifications, are crucial in melanoma development and progression.
Histone marks show potential for clinical diagnostic and prognostic value in cancers.
Understanding epigenetic changes offers opportunities for targeted melanoma therapies.

Conclusions:

Epigenetic research provides critical insights into melanoma heterogeneity and progression.
Targeting the epigenetic landscape holds promise for novel melanoma treatment strategies.
Further investigation into epigenetic markers could lead to improved melanoma diagnostics and prognostics.