[Vaccination in patients with systemic diseases]

Area of Science:

• Immunology
• Infectious Diseases
• Public Health

Background:

• The incidence of vaccine-preventable infections in patients with systemic diseases is largely unquantified.
• Existing data on vaccine immunogenicity and safety in this population are limited and of low evidence level.

Purpose of the Study:

• To review the available evidence on the safety and immunogenicity of vaccines in patients undergoing treatment for systemic diseases.
• To encourage improved vaccination practices for individuals with systemic conditions.

Main Methods:

• Literature review of studies assessing vaccine safety and immunogenicity in patients with systemic diseases.
• Analysis of existing data, acknowledging limitations in study design and sample size.

Main Results:

• Available studies indicate that vaccines are generally well-tolerated in patients with systemic diseases.
• Vaccines demonstrate immunogenicity when administered according to contraindications and established schedules.
• Despite low-level evidence, findings suggest a favorable safety and efficacy profile.

Conclusions:

• Vaccination is encouraged for patients with systemic diseases, based on current evidence of tolerability and immunogenicity.
• Strategies to enhance immunization coverage for these patients and their close contacts are recommended.
• Further high-quality research is needed to fully quantify risks and benefits.