Related Experiment Video
Updated: Jun 27, 2026

Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes
Published on: July 27, 2018
Genetic diversity among Bolivian arenaviruses
Maria N B Cajimat1, Mary Louise Milazzo, Pierre E Rollin
1Microbiology and Immunology Graduate Program, Graduate School of Biomedical Sciences, The University of Texas Medical Branch, Galveston, TX 77555-1019, USA. nbcajirm@utmb.edu
Abstract:
Machupo virus and Chapare virus are members of the Tacaribe serocomplex (virus family Arenaviridae) and etiological agents of hemorrhagic fever in humans in Bolivia. The nucleotide sequences of the complete Z genes, a large fragment of the RNA-dependent RNA polymerase genes, the complete glycoprotein precursor genes, and the complete nucleocapsid protein genes of 8 strains of Machupo virus were determined to increase our knowledge of the genetic diversity among the Bolivian arenaviruses. The results of analyses of the predicted amino acid sequences of the glycoproteins of the Machupo virus strains and Chapare virus strain 200001071 indicated that immune plasma from hemorrhagic fever cases caused by Machupo virus may prove beneficial in the treatment of Bolivian hemorrhagic fever but not hemorrhagic fever caused by Chapare virus.
Related Concept Videos
Genetic Variation
Genes exist in different versions called alleles, which...
Viral Mutations
Mutation, Gene Flow, and Genetic Drift
Viral Recombination
Arboviral Encephalitis
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

