Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis.

Pediatric nephrology (Berlin, Germany)·2024

Same author

Nutrition in critically ill children with acute kidney injury on continuous kidney replacement therapy: a 2023 executive summary.

Nutrition (Burbank, Los Angeles County, Calif.)·2023

Same author

Nutrition in Critically Ill Children with AKI on Continuous RRT: Consensus Recommendations.

Kidney360·2023

Same author

Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup.

Clinical toxicology (Philadelphia, Pa.)·2021

Same author

Pediatric Continuous Renal Replacement Therapy (PCRRT) expert committee recommendation on prescribing prolonged intermittent renal replacement therapy (PIRRT) in critically ill children.

Hemodialysis international. International Symposium on Home Hemodialysis·2020

Same author

Basics of continuous renal replacement therapy in pediatrics.

Kidney research and clinical practice·2019

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Nephrologic issues in children with developmental disabilities.

Timothy E Bunchman¹

¹Pediatric Nephrology, Dialysis, and Transplantation, Helen DeVos Children's Hospital, 221 Michigan Street Northeast, Suite 406, Grand Rapids, MI 49503, USA. timothy.bunchman@devoschildrens.org

Pediatric Clinics of North America

|December 2, 2008

Summary

Children with developmental disabilities (DD) may face kidney issues like stones and infections. Chronic kidney disease (CKD) in children can lead to developmental disabilities due to health complications. This review examines both from a nephrology perspective.

Related Experiment Videos

Last Updated: Jun 27, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Area of Science:

Pediatric Nephrology
Developmental Pediatrics
Renal Medicine

Background:

Children with developmental disabilities (DD) exhibit increased risks for renal manifestations.
These include conditions such as renal stones, hypertension, and recurrent urinary tract infections.
Conversely, pediatric chronic kidney disease (CKD) is associated with a higher incidence of DD.

Purpose of the Study:

To explore the nephrologic implications in children with developmental disabilities.
To examine the impact of chronic kidney disease on the development of disabilities in children.
To provide a comprehensive nephrologic viewpoint on the interplay between DD and CKD.

Main Methods:

Literature review of pediatric nephrology and developmental pediatrics.
Analysis of common renal manifestations in children with DD.
Examination of CKD-related factors contributing to DD in pediatric populations.

Main Results:

Children with DD are prone to specific renal issues: stones, hypertension, UTIs.
Pediatric CKD presents challenges like malnutrition and metabolic derangements, increasing DD risk.
The relationship between DD and CKD is bidirectional and complex.

Conclusions:

Understanding the nephrologic aspects is crucial for managing children with DD.
Addressing CKD complications is vital to mitigate DD in affected children.
This review highlights the importance of a multidisciplinary nephrologic approach for these vulnerable children.