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Updated: Jun 27, 2026

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

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Connexins within the rat larynx.

Mark B Van Deusen¹, Michael J Lyon

¹Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

|December 2, 2008

Summary

This study identified connexins (Cx) in the rat larynx, finding Cx43, Cx32, and Cx30 in the epiglottis, Cx43 in vocal folds, and Cx43/Cx32 in the subglottic mucosa, suggesting roles in laryngeal function and disease.

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Area of Science:

Molecular Biology
Anatomy
Physiology

Background:

Connexins (Cx) are gap junction proteins crucial for cell communication.
Understanding connexin expression in the larynx is vital for comprehending laryngeal function and pathology.

Purpose of the Study:

To identify the types and precise locations of connexins within the rat larynx.
To investigate the potential roles of these connexins in laryngeal physiology and disease.

Main Methods:

Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect connexin gene expression in laryngeal tissues.
Immunohistochemical analysis was performed to localize the identified connexins within the laryngeal structures.
The study utilized twelve larynges from adult Fisher-344 rats.

Main Results:

qRT-PCR analysis revealed the presence of Cx43, Cx32, and Cx30 in the epiglottis.
Cx43 was detected in the vocal folds, and Cx43 along with Cx32 were found in the subglottic mucosa.
Immunohistochemical staining confirmed the expression patterns and localization of these connexins.

Conclusions:

The rat epiglottis exhibits a high concentration of Cx43, Cx32, and Cx30.
The vocal folds primarily contain Cx43, while the subglottic mucosa expresses both Cx43 and Cx32.
These findings suggest that connexins are involved in laryngeal secretion and protection, potentially playing a significant role in laryngeal diseases.