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Updated: Jun 27, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Pediatric selective IgM immunodeficiency.

Marc F Goldstein¹, Alex L Goldstein, Eliot H Dunsky

¹The Asthma Center, Allergic Disease Associates, PC, 205 N. Broad street, Suite 300, Philadelphia, PA 19107, USA. gpike35@asthmacenter.com

Clinical & Developmental Immunology

|December 2, 2008

Summary

This summary is machine-generated.

Selective IgM Immunodeficiency (SIgMID) in children often presents with respiratory infections. This study found SIgMID prevalence at 0.03%, with rare severe complications like autoimmune disease or death.

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Area of Science:

Pediatric Immunology
Clinical Allergy

Background:

Selective IgM Immunodeficiency (SIgMID) is a rare primary immunodeficiency.
Limited data exists on the clinical features and prevalence of SIgMID in pediatric populations.

Purpose of the Study:

To review and analyze the features of pediatric Selective IgM Immunodeficiency.
To determine the prevalence of SIgMID in a pediatric cohort.

Main Methods:

Systematic review of English literature via PubMed and reference lists.
Analysis of 49 previously reported pediatric cases.
Inclusion of 2 new cases from an allergy/immunology practice.

Main Results:

Respiratory infections were the most common comorbidity (77.6%) in 51 reported cases.
The prevalence of SIgMID in the analyzed pediatric population was 0.03%.
No cases of lymphoproliferative disease or panhypogammaglobulinemia were observed; four fatalities occurred.

Conclusions:

The prevalence of SIgMID in pediatric patients is low (0.03%).
Recurrent respiratory infections are a hallmark of pediatric SIgMID.
Severe complications such as autoimmune disease and death are uncommon in pediatric SIgMID.