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A novel pressure-driven piezodispenser for nanoliter volumes
Shawn McGuire1, Charles Fisher, Mark Holl
1Genomation Laboratory, University of Washington, P.O. Box 352500, Seattle, Washington 98195-2500, USA.
The Review of Scientific Instruments
|December 3, 2008
Summary
A new automated pressure-driven dispensing device successfully transfers nanoliter volumes for biotechnology. This system overcomes limitations of existing microdispensers, handling higher viscosity fluids and reducing failures.
Area of Science:
- Biotechnology
- Biomedical Engineering
- Fluidics
Background:
- Nanoliter liquid transfer is crucial for biotechnology applications.
- Existing microdispensers often face challenges with air entrainment and fluid viscosity.
- Current systems frequently use valves in line with constantly pressurized fluid.
Purpose of the Study:
- To develop and validate a novel automated pressure-driven dispensing device.
- To enhance the capabilities of existing piezodriven microdispensers.
- To improve reliability and fluid handling in nanoliter dispensing.
Main Methods:
- Implementation of an automated pressure-driven system using a high-speed miniature solenoid valve.
- Control of air pressure as the primary driving force for liquid transfer.
- Integration and improvement of a typical piezodriven microdispenser.
Main Results:
- The developed device successfully dispenses nanoliter volumes of liquid.
- The system demonstrates reduced susceptibility to failures caused by air entrainment.
- The device is capable of dispensing significantly higher viscosity fluids compared to conventional microdispensers.
Conclusions:
- The novel automated pressure-driven dispensing system offers a robust solution for nanoliter liquid transfer in biotechnology.
- This technology enhances precision, reliability, and fluid compatibility for microdispensing applications.
- The system represents a significant advancement over existing microdispensing technologies.
