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In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
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Polymer samples typically consist of macromolecular chains with a distribution of lengths, resulting in a range of molar masses rather than a single discrete value. Conventional descriptors such as the number-average molar mass and weight-average molar mass quantify this distribution but do not fully capture polymer behavior in solution..The viscosity-average molar mass provides a more realistic description of polymer behavior in solution because it accounts for the enhanced contribution of...
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Viscosity

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Surface Tension
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Updated: Jun 27, 2026

Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes
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High-throughput viscosity determinations.

Jing Ma1, Jose M Lopez-Pedrosa, Mark Bradley

  • 1School of Chemistry, Joseph Black Building, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom.

The Review of Scientific Instruments
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

A novel high-throughput viscosimeter measures viscosity for 100 solutions simultaneously. This device, utilizing the falling sphere method and corrected Stokes

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Analytical Chemistry

Background:

  • Viscosity measurement is crucial for characterizing fluids.
  • Existing methods can be time-consuming for large sample sets.

Purpose of the Study:

  • To develop and validate a high-throughput viscosimeter.
  • To enable rapid viscosity determination of multiple solutions.

Main Methods:

  • Design and construction of a novel high-throughput viscosimeter.
  • Utilizing the falling sphere approach for viscosity measurement.
  • Comparison with conventional viscosimetry techniques.

Main Results:

  • The device successfully measured viscosity for 100 solutions in one experiment.
  • High correlation was observed between the new device and conventional methods.
  • Theoretical data correlated well with experimental results, confirming device robustness.

Conclusions:

  • The developed high-throughput viscosimeter is a robust and accurate tool.
  • It significantly enhances efficiency for viscosity measurements.
  • The device shows great potential for applications requiring rapid fluid characterization.