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Updated: Jun 27, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Changes in transferrin are related to changes in insulin resistance: the SLIM study
C Roumen1, E J M Feskens, E H J M Jansen
1Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.
Aims:
To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance.
Methods:
Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance.
Results:
After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids.
Conclusions:
Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism.
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