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Related Experiment Video

Updated: Jun 27, 2026

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

Performance evaluation of Abbott CELL-DYN Ruby for routine use.

T Lehto1, P Hedberg

  • 1Laboratory, Oulu University Hospital, Department of Clinical Chemistry, University of Oulu, Oulu, Finland. tiina.lehto@ppshp.fi

International Journal of Laboratory Hematology
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

The CELL-DYN Ruby hematology analyzer offers good performance for routine and emergency laboratory use. It demonstrates strong correlations with the CELL-DYN Sapphire for most complete blood count parameters and white blood cell differentials.

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Area of Science:

  • Clinical diagnostics
  • Hematology automation

Background:

  • Automated hematology analyzers are essential for accurate and efficient blood cell counting.
  • Newer instruments require rigorous evaluation to ensure reliability in clinical settings.

Purpose of the Study:

  • To evaluate the performance of the new CELL-DYN Ruby automated hematology analyzer.
  • To compare its results against the established CELL-DYN Sapphire analyzer.

Main Methods:

  • Comparative analysis of CELL-DYN Ruby against CELL-DYN Sapphire.
  • Assessment of precision, linearity, and carryover for various hematology parameters.
  • Evaluation of white blood cell (WBC) differentials.

Main Results:

  • Good precision for most complete blood count (CBC) parameters, with some exceptions at low levels (e.g., platelet count, reticulocyte percentage).
  • Strong correlation (R(2) >= 0.98) with CELL-DYN Sapphire for CBC parameters; R(2) = 0.82 for absolute reticulocyte count.
  • Good between-days precision for most WBC differentials, with higher CVs for basophils and low-count cells. Excellent correlations for neutrophils, lymphocytes, and eosinophils.

Conclusions:

  • The CELL-DYN Ruby demonstrates good performance suitable for routine use in small labs and as a backup in larger facilities.
  • The analyzer shows acceptable linearity and minimal carryover for key parameters.
  • While correlations are strong for most parameters, basophil counts showed weaker agreement, warranting attention.