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The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
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Related Experiment Video

Updated: Jun 27, 2026

Measurement of Metabolic Rate in Drosophila using Respirometry

Measurement of Metabolic Rate in Drosophila using Respirometry

Published on: June 24, 2014

Raptor swoops in on metabolism.

Reuben J Shaw¹

¹Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. shaw@salk.edu

Cell Metabolism

|December 3, 2008

Summary

The mammalian target of rapamycin complex 1 (mTORC1) is crucial for insulin signaling and cell growth. Tissue-specific knockout mice reveal mTORC1

Area of Science:

Cellular Biology
Metabolism
Physiology

Background:

The mammalian target of rapamycin (mTOR) kinase regulates cell growth and metabolism.
mTOR functions in two distinct complexes: mTORC1 and mTORC2.
mTORC1 is implicated in insulin signaling pathways.

Purpose of the Study:

To investigate the specific roles of mTORC1 in skeletal muscle and adipose tissue.
To elucidate the function of mTORC1 in insulin signaling and cellular processes within these tissues.

Main Methods:

Utilized tissue-specific knockout mouse models.
Focused on genetic manipulation to delete mTORC1 components in targeted tissues.
Analyzed physiological and molecular outcomes in skeletal muscle and adipose tissue.

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Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila

Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila

Published on: September 30, 2015

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

Measurement of Metabolic Rate in Drosophila using Respirometry

Measurement of Metabolic Rate in Drosophila using Respirometry

Published on: June 24, 2014

Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila

Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila

Published on: September 30, 2015

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

Main Results:

mTORC1 plays a key role in skeletal muscle function.
mTORC1 is essential for proper adipose tissue physiology.
These findings highlight the tissue-specific importance of mTORC1 in metabolic regulation.

Conclusions:

mTORC1 is a critical regulator of skeletal muscle and adipose tissue function.
Understanding mTORC1's role provides insights into insulin signaling and metabolic diseases.
Targeting mTORC1 may offer therapeutic strategies for metabolic disorders.