Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's proficiency in drug...
Anatomical Positions01:11

Anatomical Positions

In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Membrane association and RNA binding of recombinant hepatitis A virus protein 2C.

Archives of virology·1998
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats
05:54

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

Published on: April 4, 2019

Simulating human space physiology with bed rest.

P D Jost1

  • 1gp@peterjust.com

Hippokratia
|December 3, 2008
PubMed
Summary

Head-down bed rest effectively simulates spaceflight's physiological effects, aiding research into countermeasures for muscle wasting, bone loss, and cardiovascular issues. This research also benefits Earth-based medicine by studying sedentary lifestyle impacts.

Area of Science:

  • Space medicine
  • Human physiology
  • Bone research

Background:

  • Head-down bed rest is a validated model for simulating spaceflight's physiological effects.
  • Research aims to develop countermeasures against negative impacts of gravitational unloading.
  • Existing studies provide insights but leave questions about bone loss and recovery.

Purpose of the Study:

  • To review and synthesize knowledge from 20 years of bed rest studies.
  • To identify gaps in understanding bone loss and recovery mechanisms.
  • To highlight the relevance of bed rest research for terrestrial medicine and sedentary lifestyles.

Main Methods:

  • Review of past 20 years of bed rest studies.
  • Analysis of bone-related measurements from space programs and bed rest analogues.
Keywords:
Bed rest studystandardisation

More Related Videos

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Comprehensive Understanding of Inactivity-Induced Gait Alteration in Rodents
04:37

Comprehensive Understanding of Inactivity-Induced Gait Alteration in Rodents

Published on: July 6, 2022

Related Experiment Videos

Last Updated: Jun 27, 2026

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats
05:54

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

Published on: April 4, 2019

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Comprehensive Understanding of Inactivity-Induced Gait Alteration in Rodents
04:37

Comprehensive Understanding of Inactivity-Induced Gait Alteration in Rodents

Published on: July 6, 2022

  • Examination of metabolic and physiological data from specific bed rest studies (e.g., ESA/CNES/NASDA, WISE-2005).

    • Main Results:

    • Partial success in preventing muscle wasting, cardiovascular deconditioning, metabolic changes, and bone demineralization.
    • Evidence suggests Mediterranean diets may benefit recumbent patients.
    • A nutritional supplement preserved cardiac muscle mass, potentially aiding cardiac disease treatment.

    Conclusions:

    • Bed rest research is crucial for space exploration and understanding sedentary lifestyle effects on Earth.
    • Standardization of bed rest studies is needed for optimized results.
    • Future research, combined with in-flight validation, will address limitations in long-duration space exploration.