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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
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Lymph-node metastases in rectal carcinoids.

Yoshiya Fujimoto1, Masatoshi Oya, Hiroya Kuroyanagi

  • 1Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-10-6, Ariake, Koto-ku, Tokyo, 135-8550, Japan. yoshiya.fujimoto@jfcr.or.jp

Langenbeck'S Archives of Surgery
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Summary

Rectal carcinoid tumors frequently have lymph node metastasis, impacting survival similarly to adenocarcinomas. Tumor size, lymphovascular invasion, and preoperative CT findings of enlarged lymph nodes are key indicators.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pathology

Background:

  • Colorectal carcinoids are classified as low-grade malignancies.
  • Survival rates for carcinoids with metastasis are comparable to adenocarcinomas.

Purpose of the Study:

  • To investigate the prevalence of lymph node metastasis in rectal carcinoids.
  • To identify predictive factors for lymph node metastasis in rectal carcinoid tumors.

Main Methods:

  • Retrospective review of 17 patients with rectal carcinoid undergoing surgical resection and lymph node dissection (March 2005 - November 2007).
  • Inclusion criteria: tumor size ≥ 10 mm, positive resection margin, or lymphovascular invasion.

Main Results:

  • Lymph node metastases were found in 12 of 17 patients.
  • Tumor size < 10 mm with lymphovascular invasion was observed in 3 patients with metastasis.
  • Preoperative CT identified lymph nodes ≥ 5 mm in 8 patients with lymph node metastasis.

Conclusions:

  • Rectal carcinoids commonly present with lymph node metastasis.
  • Tumor size (≥ 10 mm) and lymphovascular invasion are significant predictors of metastasis.
  • Preoperative CT detection of lymph nodes ≥ 5 mm suggests metastasis.