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HLA class II nucleotide sequences, 1991.

S G Marsh1, J G Bodmer

  • 1Imperial Cancer Research Fund, London, United Kingdom.

Immunogenetics
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Nomenclature for factors of the HLA system, update April 2001.

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Nomenclature for factors of the HLA system, update May 2001.

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The HLA Dictionary 2001: a summary of HLA-A, -B, -C, -DRB1/3/4/5 and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR and -DQ antigens.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics·2002

This compilation presents Human Leukocyte Antigen (HLA) class II sequences, ensuring accuracy through author contact and incorporating nomenclature updates. It aims to provide a reliable resource for researchers studying HLA variations.

Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • Human Leukocyte Antigen (HLA) class II genes are crucial for immune response.
  • Accurate sequence data is vital for understanding HLA diversity and its role in disease.

Purpose of the Study:

  • To compile and standardize available Human Leukocyte Antigen (HLA) class II sequences.
  • To create a reliable and accurate sequence alignment for research purposes.

Main Methods:

  • Sequences were gathered from published literature, adhering to established HLA nomenclature (1990 and 1989).
  • Discrepancies were resolved by contacting original authors for amendments.
  • Sequence alignments were generated, using hyphens for identity, asterisks for unavailable data, and gaps for alignment.

Main Results:

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  • A comprehensive compilation of HLA class II sequences has been established.
  • The alignment incorporates amendments based on direct author communication, enhancing data integrity.
  • Standardized notation for sequence identity, unavailability, and gaps is applied.

Conclusions:

  • The compiled HLA class II sequence data serves as a valuable, accurate resource for the scientific community.
  • Continuous efforts to maintain accuracy through future updates and evidence are welcomed.
  • This standardized alignment facilitates comparative studies of HLA alleles and their variations.