Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic buccal mucosal graft ureteroplasty: a contemporary multi-institutional experience.

World journal of urology·2026
Same author

Trauma and Genital and Urethral Reconstruction.

The Journal of urology·2026
Same author

Trauma and Genital and Urethral Reconstruction.

The Journal of urology·2026
Same author

Trauma and Genital and Urethral Reconstruction.

The Journal of urology·2026
Same author

Trauma, and Genital and Urethral Reconstruction.

The Journal of urology·2026
Same author

Trauma, and Genital and Urethral Reconstruction.

The Journal of urology·2026

Related Experiment Video

Updated: Jun 27, 2026

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Antimicrobial-resistant pathogens: an emerging pediatric threat.

Sean P Elliott1

  • 1Department of Pediatrics, Steele Children's Research Center, Arizona Health Sciences Center, 1501 North Campbell Avenue, #245073, Tucson, AZ 85724-5073, USA. selliott@peds.arizona.edu

Advances in Pediatrics
|December 4, 2008
PubMed
Summary

Pediatric bacterial threats like CA-MRSA and MDR pneumococci challenge antimicrobial options. Careful stewardship and management of new drugs are crucial for patient outcomes and future efficacy.

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Related Experiment Videos

Last Updated: Jun 27, 2026

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pediatrics

Background:

  • * Increasing prevalence of pediatric bacterial infections poses significant clinical challenges.
  • * Key threats include community-associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA), multidrug-resistant (MDR) Streptococcus pneumoniae, and multidrug-resistant Gram-negative bacilli (MDRGN).
  • * These pathogens are associated with treatment failures and complicate patient care.

Purpose of the Study:

  • * To highlight the clinical impact of CA-MRSA, MDR pneumococci, and MDRGN in pediatric populations.
  • * To emphasize the need for effective antimicrobial stewardship.
  • * To discuss strategies for mitigating the challenges posed by these resistant bacteria.

Main Methods:

  • * Review of clinical and epidemiologic factors associated with CA-MRSA, MDR pneumococci, and MDRGN.
  • * Analysis of current antimicrobial treatment options and their limitations.
  • * Discussion of antimicrobial stewardship principles and future drug development.

Main Results:

  • * CA-MRSA, MDR pneumococci, and MDRGN present substantial virulence and resistance challenges.
  • * Existing antimicrobial options face a high threat of failure against these pathogens.
  • * Knowledge of organism-specific factors is vital for effective management.

Conclusions:

  • * Antimicrobial stewardship and understanding of bacterial epidemiology are essential to mitigate patient impact.
  • * Careful management of new antimicrobial agents is critical to preserve their future efficacy.
  • * Ongoing research and discovery of novel antimicrobial therapies are necessary.