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Published on: March 14, 2017
Pain Management in Pediatric Patients with Sickle Cell Disease
Marni Shear1, Peter Huynh2, Gloria Sanchez3
1Department of Pediatrics, Harbor UCLA Medical Center, The Lundquist Institute of Biomedical Innovation, David Geffen School of Medicine at UCLA, Torrance, CA, USA.
Advances in Pediatrics
|July 21, 2026
Summary
Sickle cell pain management requires personalized care. Emerging therapies aim to reduce vaso-occlusive episodes (VOEs), complementing traditional opioid use and non-pharmacologic interventions.
Area of Science:
- Hematology
- Pain Medicine
- Pediatrics
Background:
- Sickle cell pain is a complex, individualized condition.
- Opioids are standard for acute vaso-occlusive episodes (VOEs).
- Biopsychosocial factors influence pain experience.
Purpose of the Study:
- To review current and emerging strategies for sickle cell pain management.
- To highlight the role of disease-modifying therapies.
- To explore adjunct non-pharmacologic and nonopioid options.
Main Methods:
- Literature review of current pain management approaches.
- Analysis of emerging disease-modifying therapies.
- Evaluation of nonopioid and nonpharmacologic interventions.
Main Results:
- Opioids remain crucial for acute VOE pain.
- New disease-modifying therapies show promise in reducing VOE frequency and duration.
- Nonopioid analgesics and nonpharmacologic methods offer supportive roles.
Conclusions:
- Personalized pain management is essential for sickle cell disease.
- Disease-modifying therapies represent a significant advancement.
- Integrated approaches including nonpharmacologic options enhance care for pediatric patients.
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