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Polymer embedded nanocrystalline titania sorbent for 99Mo-99mTc generator
Rubel Chakravarty1, Rakesh Shukla, Shyamla Gandhi
1Radiopharmaceuticals Division, 2 Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Journal of Nanoscience and Nanotechnology
|December 4, 2008
Summary
A novel polymer-titania sorbent efficiently adsorbs 99Mo, a precursor for 99mTc radiopharmaceuticals. This material shows promise for developing reliable 99Mo-99mTc generators with high elution yields.
Area of Science:
- Materials Science
- Radiochemistry
- Nuclear Medicine
Background:
- 99mTc is a crucial radioisotope for medical imaging.
- Development of efficient 99Mo-99mTc generators is vital for radio-pharmaceutical supply.
- Novel sorbent materials are needed for improved adsorption and elution characteristics.
Purpose of the Study:
- To develop and characterize a new sorbent material, polymer embedded nano crystalline titania (TiP).
- To evaluate the potential of TiP for the adsorption of 99Mo and the subsequent elution of 99mTc.
- To assess the suitability of the TiP-based generator for radiopharmaceutical applications.
Main Methods:
- Synthesis of polymer embedded nano crystalline titania (TiP) from titanium (IV) chloride and isopropyl alcohol.
- Characterization using infrared absorption spectra, X-ray diffraction, and Transmission Electron Microscopy (TEM).
- Adsorption of 99Mo at pH 1 and elution of 99mTc using 0.9% saline solution.
Main Results:
- TiP characterization confirmed the presence of Ti-O groups, rutile TiO2 structure, a surface area of 30 m2/g, and an average crystallite size of 5 nm.
- The adsorbent demonstrated effective adsorption of 99Mo and elution of 99mTc with an approximate yield of 80%.
- The eluted 99mTc met international radiopharmaceutical quality standards, and consistent results were obtained over a week-long test run.
Conclusions:
- Polymer embedded nano crystalline titania (TiP) is a promising sorbent for 99Mo-99mTc generators.
- The developed TiP material facilitates efficient 99mTc elution suitable for radiopharmaceutical use.
- TiP-based generators offer consistent performance within the typical shelf life of 99Mo-99mTc generators.
