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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Published on: February 6, 2021

Endophthalmitis caused by Enterococcus faecalis: a case series.

Ekta Rishi1, Pukhraj Rishi, Krishnendu Nandi

  • 1Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India. docrishi@yahoo.co.in

Retina (Philadelphia, Pa.)
|December 4, 2008
PubMed
Summary
This summary is machine-generated.

Enterococcus faecalis endophthalmitis is often caused by surgery or trauma. Early surgical intervention and Vancomycin treatment can lead to good visual outcomes in these cases.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Endophthalmitis is a serious intraocular infection.
  • Enterococcus faecalis is a significant pathogen causing endophthalmitis.
  • Understanding the etiology and outcomes is crucial for effective management.

Purpose of the Study:

  • To investigate the causes, clinical presentation, and treatment outcomes of Enterococcus faecalis endophthalmitis.
  • To evaluate the effectiveness of current treatment modalities.
  • To identify factors influencing visual and anatomical results.

Main Methods:

  • Retrospective case series at a tertiary ophthalmic hospital in South India.
  • Analysis of clinical and microbiological data from 26 eyes with culture-positive E. faecalis endophthalmitis.
  • Review of treatment strategies including vitrectomy and intravitreal injections.

Main Results:

  • The most common causes were post-surgical (12 eyes) and post-traumatic (11 eyes).
  • Initial visual acuity averaged 3.19 logMAR, improving to 2.12 logMAR post-treatment.
  • A significant proportion of eyes (30.7%) had poor anatomical outcomes, but visual outcomes were statistically significant (P = 0.008).
  • Nearly all isolates were sensitive to Vancomycin.

Conclusions:

  • Surgery and trauma are leading causes of E. faecalis endophthalmitis.
  • Early surgical intervention is associated with favorable functional outcomes.
  • Vancomycin demonstrates high sensitivity and can be considered a first-line treatment.